How do you dilute MMR vaccine?

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To reconstitute, use only the diluent supplied with the vaccine since it is free of preservatives or other antiviral substances which might inactivate the vaccine. Withdraw the entire volume of the supplied diluent from its vial and inject into lyophilized vaccine vial. Agitate to dissolve completely.

How much diluent is used for M-M-R?

M-M-R®II vaccine is a suspension for injection supplied as a single dose vial of lyophilized vaccine to be reconstituted using the accompanying sterile diluent. A single dose after reconstitution is 0.5 mL.

What is a sterile diluent?

(a) Sterile Diluent may be distilled or deionized water or it may be a special liquid solution formulated in accordance with an acceptable outline on file with Animal and Plant Health Inspection Service.

Does MMR vaccine need to be reconstituted?

Both vaccines contain live, attenuated measles, mumps, and rubella virus. MMRV also contains live, attenuated varicella-zoster virus. The lyophilized live MMR vaccine and MMRV vaccine should be reconstituted and administered as recommended by the manufacturer1,2.

What vaccines need a diluent?

However, 11 vaccines need to be reconstituted before being administered: ActHib®, Hiberix®, Menveo®, Menomune®, M-M-R II®, Pentacel®, ProQuad®, Rotarix®, TriHIBit®, Varivax®, and Zostavax®. To reconstitute a vaccine, a lyophilized (freeze-dried) vaccine in one vial must be mixed with a diluent (liquid) in another.

Does sterile diluent need to be refrigerated?

Both powder and diluent should be stored at 35°F-46°F. The lyophilized pellet may be stored at freezer temperature; the reconstituted vaccine should be stored at refrigerator temperature.

What is diluent for vaccines?

A vaccine diluent is the liquid mixed with a lyophilized (freeze-dried) vaccine in order to reconstitute the lyophilized vaccine and provide the final vaccine for administration. A vaccine diluent may be sensitive to heat or freezing, and may require transportation and storage in the cold chain.

Which vaccines must be reconstituted with a liquid diluent?

Most vaccines come ready to administer in vials or prefilled syringes. However, 11 vaccines need to be reconstituted before being administered: ActHib®, Hiberix®, Menveo®, Menomune®, M-M-R II®, Pentacel®, ProQuad®, Rotarix®, TriHIBit®, Varivax®, and Zostavax®.

Is sterile diluent the same as sterile water?

STERILE DILUENT(sterile water for injection)

Does MMR diluent need to be refrigerated?

The diluent can be stored in the refrigerator or at room temperature but should not be allowed to freeze.

How do you administer MMR?

For Adults. The dosage for MMR vaccine is 0.5 mL by the subcutaneous route. If a second dose is indicated, the minimum interval between the first and second doses should be separated by at least 4 weeks (28 days). The preferred injection site for adults is the posterior triceps aspect of the upper arm.

What happens if MMR vaccine is administered intramuscularly?

All live injected vaccines (MMR, varicella, and yellow fever) are recommended to be given subcutaneously. However, intramuscular administration of any of these vaccines is not likely to decrease immunogenicity, and doses given IM do not need to be repeated.