What does Pseudomonas aeruginosa do in response to quorum sensing?

Pseudomonas aeruginosa is an opportunistic pathogen of humans that uses a process called quorum sensing (QS) to regulate gene transcription in response to cell density (1, 2). The P. aeruginosa genome encodes two complete acyl-homoserine lactone (AHL) QS systems: the LasR-LasI system and the RhlR-RhlI system.

How does quorum sensing enable Pseudomonas aeruginosa to cause disease?

The autoinducer found inside this system is called rhlI, with this system also playing a role in producing LasB in an optimal manner. In terms of human infection, the cell-to-cell interaction involved in Quorum sensing may have a role in enabling Pseudomonas aeruginosa to by-pass the host’s immune system.

How can quorum sensing be used to fight bacterial infections?

Quorum sensing is thought to afford pathogenic bacteria a mechanism to minimize host immune responses by delaying the production of tissue-damaging virulence factors until sufficient bacteria have amassed and are prepared to overwhelm host defense mechanisms and establish infection.

Is Pseudomonas aeruginosa a biofilm?

Pseudomonas aeruginosa is an opportunistic bacterial pathogen responsible for both acute and chronic infections in humans. In particular, its ability to form biofilm, on biotic and abiotic surfaces, makes it particularly resistant to host’s immune defenses and current antibiotic therapies as well.

Is quorum sensing a virulence factor?

Abstract. Quorum sensing (QS) is a key regulator of virulence factors and biofilm formation in Gram-negative bacteria such as Pseudomonas aeruginosa. Microorganisms that inhabit soil are of strategic importance in the discovery of compounds with anti-QS properties.

How does quorum sensing make some bacteria more likely to cause disease?

Its ability to cause disease depends on expression of an array of adhesion molecules, toxins, and compounds that affect the immune system. QS regulates expression of genes encoding these virulence factors. S.

What is the significance of quorum sensing in bacterial resistance?

The QS system plays an important role in the formation of bacterial drug resistance mechanisms by regulating the formation of biofilms and the direct regulation of drug efflux pumps.

What bacterial genes are often regulated by quorum sensing?

Among the many traits controlled by quorum sensing is the expression of virulence factors by pathogenic bacteria. Here we review the quorum-sensing circuits of Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa, and Vibrio cholerae.