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Does phenobarbital induce microsomal enzymes?

Does phenobarbital induce microsomal enzymes?

PHENOBARBITAL-INDUCED SYNTHESIS OF THE MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEM AND ITS RELATIONSHIP TO THE PROLIFERATION OF ENDOPLASMIC MEMBRANES – PMC. The .

Does phenobarbital cause enzyme induction?

Enzyme induction is important in the pathogenesis of hepatotoxicity and therapeutic failure of many drugs. Phenobarbital is a potent enzyme inducer known for hepatotoxicity and for inducing its own metabolism.

What enzyme does phenobarbital induce?

cytochrome P450 enzyme inducer
Phenobarbital is a potent cytochrome P450 enzyme inducer, leading to interactions with other drugs by increasing their clearance.

What is the importance of enzyme induction caused by barbiturate drugs?

Chronic use of barbiturates will cause upregulation, or induction, of the microsomal enzymes (CYPs 1A2, 2C9, 2C19, and 3A4), increasing the metabolism of drugs metabolized by these enzymes. This can lead to patients requiring larger dosages of medication to achieve therapeutic effect and/or increased clearance.

What is the effect of hepatic microsomal enzyme inducers on the phenobarbitone sleeping time in mice?

To study effect of hepatic microsomal enzyme inducers on the phenobarbitone sleeping time in mice. Principal : Biotransformation may affect binding and storage of drug molecules within the body and may other increase or decrease the effect of the absorbed drug.

What is the action of phenobarbital?

Phenobarbital belongs to a class of drugs known as barbiturate anticonvulsants/hypnotics. It works by controlling the abnormal electrical activity in the brain that occurs during a seizure.

How does hepatic microsomal enzyme induction influence drug actions and effects?

The evidence suggests that foreign chemicals exert this action by increasing the amount of drug-metabolizing enzymes in liver microsomes. Treatment of animals or man with suitable inducers of liver microsomal enzymes accelerates drug metabolism in vivo and alters the duration and intensity of drug action.

How do enzyme inducer and enzyme inhibitor affect drug effect?

Enzyme induction and drug interactions Enzyme induction refers to an increase in the rate of hepatic metabolism, mediated by increased transcription of mRNA encoding the genes for drug-metabolizing enzymes. This leads to a decrease in the concentrations of drugs metabolized by the same enzyme.

What is the function of phenobarbital?

Phenobarbital is used to control seizures. Phenobarbital is also used to relieve anxiety. It is also used to prevent withdrawal symptoms in people who are dependent (‘addicted’; feel a need to continue taking the medication) on another barbiturate medication and are going to stop taking the medication.

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