Does reovirus have a segmented genome?

Reoviruses also have segmented genomes, packaging 11–12 segments of dsRNA. Reoviruses are nonenveloped and particles consist of two or three concentric icosahedral capsid layers. The genome segments are found within the innermost, T=1 icosahedral shell.

How many segments does reovirus have?

The genomes of viruses in family Reoviridae contain 10–12 segments which are grouped into three categories corresponding to their size: L (large), M (medium) and S (small). Segments range from about 0.2 to 3 kbp and each segment encodes 1–3 proteins (10–14 proteins in total).

How many ds DNA segments are present in the reovirus genome?

It contains 15 genera of viruses having genomes composed of 9, 10, 11 or 12 segments of linear dsRNA.

How many double-stranded RNA segments are present in the reovirus genome?

Reovirus particles can contain 9, 10, 11 or 12 segments of linear dsRNA, depending on the genus. The individual Mr of these RNA molecules ranges from 0.2 to 3.0×106. The total Mr of the genome is 12–20×106. The RNA constitutes about 15–20% of the virion dry weight.

What happens in reovirus?

Reovirus is a nonenveloped double-stranded RNA virus. This virus was initially not known to be related to any specific disease, and so was named Respiratory Enteric Orphan virus. However, some members of the reovirus family have been shown to cause mild illnesses such as diarrhea [5,30].

What does reovirus stand for?

The name “REO” is actually an acronym referring to respiratory enteric orphan. The first two aspects of the name are the result of research done on the very first reoviruses known, which were isolated from both the respiratory tract and the enteric tract.

What are the characteristics of reovirus?

Important features of the orthoreoviruses (or “reoviruses”) include a diameter of 70 nm; a double capsid; ether and acid stability; a genome of 10 segments of double-stranded RNA; three serotypes designated types 1, 2, and 3; and the ability to infect humans as well as various other animals.

How do you get reovirus?

The method of transmission of reoviruses is unknown. However, because these viruses are recovered most frequently from the feces, primary spread seems most likely to be by the fecal-oral route.

Does reovirus have double-stranded RNA?

Double-stranded RNA viruses include the rotaviruses, known globally as a common cause of gastroenteritis in young children, and bluetongue virus, an economically significant pathogen of cattle and sheep. The family Reoviridae is the largest and most diverse dsRNA virus family in terms of host range.

What is the genetic material of reovirus?

The genome of reovirus consists of ten unique segments of double-stranded (ds) RNA which are packaged within a double-shelled capsid composed of protein subunits (Bellamy et al., 1967; Shatkin et al., 1968; Watanabe et al., 1968) (Fig.

Is reovirus positive or negative sense?

Reovirus ssRNAs are translated to synthesize new viral proteins and also serve as templates for negative-sense ssRNA synthesis within the replicase particles to produce nascent genomic dsRNA [15,16].