Guidelines

How do you write C. elegans?

How do you write C. elegans?

Homologous Genes elegans gene is identified in a related species such as Caenorhabditis briggsae, it can be given the same gene name, preceded by two italic letters referring to the species, and a hyphen. For example, Cb-tra-1 is the name for the C. briggsae homolog of the C. elegans gene tra-1 .

What are C. elegans classified as?

Caenorhabditis elegans (/ˌsiːnoʊræbˈdaɪtəs ˈɛləɡæns/) is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments. It is the type species of its genus.

Should C. elegans be italicized?

All C. elegans gene names, allele designations, and reporter genes are written in italics. Cosmids, proteins, phenotypes, and strain names are not written in italics.

Are C. elegans genetically invariant?

elegans in developmental biology? For developmental biologists, the biggest advantage of C. elegans is its “invariant lineage”. This means that every embryo develops with the exact same pattern of cell divisions and cell migrations and hatches with the exact same complement of 558 cells.

Are gene mutations italicized?

Gene names that are written out in full are not italicized (e.g., insulin-like growth factor 1). Genotype designations should be italicized, whereas phenotype designations should not be italicized.

How do you read gene names?

Nomenclature generally follows the conventions of human nomenclature. Gene symbols generally are italicised, with all letters in uppercase (e.g., NLGN1, for neuroligin1). Protein designations are the same as the gene symbol, but are not italicised; all letters are in uppercase (NLGN1).

Why C. elegans is used as a model organism?

C. elegans is a nematode worm and is significantly anatomically simpler than a human, however, it does share many similarities at the molecular level making it a good candidate for a model organism.

What is meant by invariant cell lineage in C. elegans?

As already mentioned the strict concept of a determi- nate mode of development with an invariant lineage implies that the lineage ‘itself’ assembles the body by its stereotyped cleavage pattern and that the cell is the fundamental unit of organization.

Why C. elegans is considered a model organism?

How do you write a mutant gene?

Mutant gene symbols should have three letters (underlined or italics) written in lower case letters (abc). Some gene symbols chosen before these guidelines were established may have two letters. The wild-type allele should be written (underlined or italics) in capital letters (ABC).

How do you write a mutant genotype?

For spontaneously or targeted mutant mice, this notation makes perfect sense: “+” indicates the wildtype allele, and “-” the mutant allele. Thus, we designate our mouse genotypes “-/-” for homozygous mutants, “+/-” for heterozygotes, and “+/+” for wildtypes.

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