In which drug umbelliferone constituent present*?
Umbelliferone is a 7-hydroxycoumarin that is a pharmacologically active agent. It is widely distributed within the Rutaceae and Apiaceae (Umbelliferae) families and is efficiently extracted using methanol. Umbelliferone is a fluorescing compound used as a sunscreen agent.
Is Umbelliferone polar?
Umbelliferone is a hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7. It has a role as a fluorescent probe, a plant metabolite and a food component….3.2.5Kovats Retention Index.
|Standard non-polar||1789, 1795, 1797, 1828|
|Semi-standard non-polar||1852.5, 1828, 1836|
What is combined Umbelliferone test?
Combined Umbelliferone test Triturate the drug (if in tear form) with sand. Boil 0.5 g of the drug with 3 ml of hydrochloric acid and 3 ml of water for 5 to 10 min. filter and to the filtrate add an equal volume of alcohol and excess of strong solution of ammonia.
How do coumarins work?
Coumarin derivatives (4-hydroxycoumarin compounds) are oral anticoagulants (OA) that prevent vitamin K from acting as a cofactor in the hepatic synthesis of the vitamin K-dependent coagulation factors II, VII, IX, and X (as well as the anticoagulants, proteins C and S). They are also called vitamin K antagonists (VKA).
Which resin is present in asafoetida?
Asafoetida is used as a flavoring agent in food and as a traditional medicine for many diseases in many parts of the world. Asafoetida (Ferula asafoetida) is an oleo-gum-resin obtained from the stems of Ferula plants belonging to the family Umbelliferae.
What is main chemical constituent of asafoetida?
Typical asafoetida contains about 40–64% resin, 25% endogeneous gum, 10–17% volatile oil, and 1.5–10% ash. The resin portion is known to contain asaresinotannols A and B, ferulic acid, umbelliferone and four unidentified compounds.
Are coumarins aromatic?
Coumarin is an aromatic compound that has a bicyclic structure with lactone carbonyl groups. The presence of an electronegative atom is effective for hydrogen bond formation and for solubility, to some extent and aromatic ring is responsible for having hydrophobicity.