Is Sertoli cell tumor cancer?
Sertoli cell tumors are rare benign neoplasms in which Sertoli cells line tubules or grow in trabeculae. They lack the primitive stroma and Leydig cells that are present in Sertoli-Leydig cell tumors. Oxyphilic and lipid-rich variants have been described,553 and Sertoli cell tumors can contain areas of diffuse growth.
What percentage of Leydig cell Tumours is malignant in females?
They are generally benign tumors with only 5% to 10% being considered malignant and have a bimodal distribution with peaks in the prepubertal age group and between the ages of 30 to 60. Due to Leydig cells’ hormonally active properties, they can present with precocious puberty, breast tenderness, or gynecomastia.
What is the female version of Sertoli cells?
Granulosa cells are the female equivalent of the Sertoli cells; they enclose germ cells and secrete factors necessary for oocyte growth and maturation.
Can Sertoli-Leydig come back?
Highlights. Sertoli–Leydig cell tumour (SLCT) relapses occur early after the initial diagnosis and have a poor prognosis. The majority of SLCT relapses are located in the abdominopelvic region.
What is the role of Sertoli cell?
Sertoli cells are the somatic cells of the testis that are essential for testis formation and spermatogenesis. Sertoli cells facilitate the progression of germ cells to spermatozoa via direct contact and by controlling the environment milieu within the seminiferous tubules.
Is Leydig cell tumor cancer?
Leydig cell tumors are usually benign, but appproximately 10% are malignant. As with germ cell tumors, the route of spread is hematogenous and lymphatic to the retroperitoneal lymph nodes. Unlike germ cell tumors, however, Leydig cell tumors show relative lack of sensitivity to radiotherapy and chemotherapy agents.
How is Sertoli cell tumor diagnosed?
On ultrasound, a Sertoli cell tumour appears as a hypoechoic intratesticular lesion which is usually solitary. However, the large cell subtype might present as multiple and bilateral masses with large areas of calcification. An MRI may also be conducted, but this typically is not definitive.
Are Leydig cell tumors benign?
Do Sertoli cell tumors produce estrogen?
Sertoli cell tumors release estrogen which can lead to myelotoxicity (10). Estrogen toxicity on the bone marrow has been well-studied. The initial stage is characterized by an increased production of neutrophils and a significant leukocytosis characterized by a neutrophilia (11).