What is atazanavir cobicistat used for?

What is atazanavir cobicistat used for?

ATAZANAVIR; COBICISTAT (at a za NA veer; koe BIS i stat) is an antiretroviral medicine and a medication booster in 1 tablet. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. This medicine can lower, but not fully prevent, the risk of spreading HIV to others.

What is the generic name for darunavir?

Darunavir is a medication used to treat HIV. It is marketed under the brand name Prezista, but generic versions are also available. It is taken in combination with other antiretroviral drugs. The usual adult dose of darunavir is 800mg taken once a day, with a booster drug.

Is cobicistat a strong CYP3A4 inhibitor?

Cobicistat and ritonavir are equally strong inhibitors of cytochrome P450 (CYP) 3A4 and consequently were shown to be equivalent pharmacokinetic enhancers for elvitegravir and for the PIs atazanavir and darunavir.

Why is ritonavir combined with atazanavir?

Atazanavir/ritonavir is as effective as lopinavir/ritonavir, with a more favourable lipid profile and less gastrointestinal toxicity, in treatment-experienced HIV-1-infected patients. We compared these two combinations directly in treatment-naive patients.

What kind of drug is cobicistat?

Cobicistat, sold under the brand name Tybost, is a medication for use in the treatment of human immunodeficiency virus infection (HIV/AIDS). Its major mechanism of action is through the inhibition of human CYP3A proteins.

What is the brand Name for darunavir?

Darunavir (brand name: Prezista) is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children.

Who makes darunavir?

FDA Approves New 800mg PREZISTA® (darunavir) Tablet | Johnson & Johnson.

Is cobicistat a Pgp inhibitor?

COBI is a substrate of Pgp and BCRP and likely has a competitive mode of inhibition with coadministered agents.

What is darunavir ritonavir?

Darunavir is used with a pharmacokinetic booster (a medication that increases the amount of other medications in the body) such as ritonavir (Norvir) or cobicistat (Tybost), and other medications to treat human immunodeficiency virus (HIV) infection in adults and children 3 years of age and older.

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