What is histidine monohydrochloride?
l-Histidine monohydrochloride monohydrate is an off-white, odourless, colourless and crystalline powder, with a bulk density of 550–750 kg/m3, melting point at 254°C, pH 3.5–4.5 (1% solution in water) and a water solubility of 56.6 g/L at 25°C.
What is DL histidine?
Histidine is an alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3. It has a role as a metabolite. It is an alpha-amino acid, a member of imidazoles, an aromatic amino acid and a polar amino acid. It contains a 1H-imidazol-4-ylmethyl group.
Is L histidine monohydrochloride monohydrate safe?
glutamicumKCCM 80179 supplemented at levels appropriate for the requirements of species and life stage is considered safe for the consumer. l‐Histidine HCl monohydrate produced using C. glutamicum KCCM 80179 is not irritant to skin, is mildly irritant to eyes, and it is not a skin sensitiser.
What is histidine hydrochloride monohydrate used for?
People use histidine as medicine. Some people take histidine by mouth for metabolic syndrome, diarrhea caused by cholera infection, rheumatoid arthritis, allergic diseases, ulcers, and anemia caused by kidney failure or kidney dialysis.
Does histidine help eczema?
L-histidine is an amino acid that the human body cannot make and therefore can only be obtained by diet. It is an essential part of the skin barrier and contributes to maintaining skin hydration, both important in preventing and treating eczema.
What foods contain L-histidine?
Foods rich in histidine are generally protein rich foods such as meat, dairy products, legumes, fish, nuts, seeds, eggs and whole grains.
Why is histidine protonated at pH 7?
Since the imidazole group on histidine has a pKa of 6.0, a solution with a pH of 7 will favor the negative ion on the functional group of histidine. While a low pH (less than 6) solution adds an H+ to the group, a high pH (greater than 6) reacts aqueous OH- with the hydrogen on the functional group.
Does histidine make you sleepy?
Histidine decreased the POMS fatigue score in men feeling fatigue and drowsiness. Histidine shortened reaction times on a cognitive function battery test.
What are the side effects of L histidine?
At high doses, histidine may have adverse effects on cognitive function and sleep. In infants treated with parenteral histidine at dose levels of 24–65 g/d, Zlotkin (39) reported anorexia, painful sensations in the eye area, and vision disturbances.
How much L histidine should I take for eczema?
L-histidine explored as an oral eczema treatment A study conducted in 2017 showed that 4g of L-histidine taken by mouth daily for eight weeks reduced eczema symptom severity, and that effect was comparable to a mid-level topical steroid.
What foods contain L histidine?