What is IDH status?
Determination of the isocitrate dehydrogenase (IDH) mutation status, presence or absence of mutation in IDH genes (IDH1 or IDH2), has become one of the most important molecular features taken into account in the management of patients with diffuse gliomas.
What is IDH in tumors?
Isocitrate dehydrogenase (IDH) is an essential enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle. Recurrent mutations in IDH1 or IDH2 are prevalent in several cancers including glioma, acute myeloid leukemia (AML), cholangiocarcinoma and chondrosarcoma.
How long can you live with glioma?
Survival rates for more common adult brain and spinal cord tumors
| Type of Tumor | 5-Year Relative Survival Rate | |
|---|---|---|
| Low-grade (diffuse) astrocytoma | 73% | 26% |
| Anaplastic astrocytoma | 58% | 15% |
| Glioblastoma | 22% | 6% |
| Oligodendroglioma | 90% | 69% |
What is IDH gene?
The IDH1 gene provides instructions for making an enzyme called isocitrate dehydrogenase 1. This enzyme is primarily found in the fluid-filled space inside cells (the cytoplasm). It is also found in cellular structures called peroxisomes, which are small sacs within cells that process many types of molecules.
What causes IDH?
Smoking, consuming alcohol, obesity, and high blood fat may lead to IDH. Additionally, certain groups of people have an increased risk of IDH, including younger males and people with diabetes or previous cardiovascular events.
What is the best treatment for glioma?
The best treatment for glioblastoma currently is surgery to remove as much of the tumour as possible, followed by a combination of chemotherapy and radiotherapy.
Can gliomas be cured?
High-grade glioma High-grade gliomas cannot be cured. Quality of life issues are important to consider in the treatment of patients with high-grade glioma.