What is the Bcl-2 gene?
A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome 18, and transfer of the BCL2 gene to a different chromosome is seen in many B-cell leukemias and lymphomas.
Is Bcl-2 a transcription factor?
This work presents direct evidence that the bcl-2 gene is transcriptionally regulated by nuclear factor-κB (NF-κB) and directly links the TNF-α/NF-κB signaling pathway with Bcl-2 expression and its pro-survival response in human prostate carcinoma cells.
Why is Bcl-2 a cell survival factor?
The discovery of Bcl-2 established a new paradigm in cancer biology, namely that defects in apoptosis bestow cells with a selective survival advantage, that when combined with mutations that facilitate unrestrained proliferation (e.g., deregulated c-myc expression), can promote malignant transformation.
What is Bcl-2 name?
Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.
What kind of protein is BCL2?
Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis. It was the first apoptosis regulator identified in any organism. Chr.
How does BCL2 cause apoptosis?
BCL2 prevents BAX/BAK oligomerization, which would otherwise lead to the release of several apoptogenic molecules from the mitochondrion. It is also known that BCL2 binds to and inactivates BAX and other pro-apoptotic proteins, thereby inhibiting apoptosis.
Is BCL2 a positive or negative regulator of programmed cell death?
Among the anti-apoptotic members, Bcl-2 and Bcl-XL are negative regulators of cell death, preventing cells from undergoing apoptosis induced by various stimuli in a wide variety of cell types,16,17 whereas others, such as Bax and Bid promote or accelerate cell death.
Do T cells express BCL2?
Bcl-2 is expressed at high levels in memory phenotype CD8+, but not CD4+ T cells.
What do BCL2 inhibitors do?
A selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon administration, Bcl-2 inhibitor BCL201 binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells.
Is BCL2 anti apoptotic?
Prosurvival or Antiapoptotic Family Members. BCL2 (and its antiapoptotic orthologues) seems to inhibit apoptosis by the preservation of mitochondrial membrane integrity as its hydrophobic carboxyl-terminal domain is linked to the outer membrane.