When did tamoxifen come on the market?
It is a selective estrogen-receptor modulator (SERM) and works by decreasing the growth of breast cancer cells. It is a member of the triphenylethylene group of compounds. Tamoxifen was initially made in 1962, by chemist Dora Richardson. It is on the World Health Organization’s List of Essential Medicines.
What is the retail price of tamoxifen?
About Tamoxifen It may also help prevent breast cancer in women who have a high risk of developing breast cancer. The lowest GoodRx price for the most common version of tamoxifen is around $16.50, 76% off the average retail price of $69.90.
Is there still a tamoxifen shortage?
There have been some really alarming and scary headlines floating around. But the fact is Tamoxifen is still available, there is just less of it. To help everyone get through the temporary shortage, patients may only get 30-days of their prescriptions at a time.
Why is there a tamoxifen shortage?
According to Health Canada, there’s a national shortage of Tamoxifen due to manufacturing disruptions and increased demand. There is an international shortage of a common cancer drug called Tamoxifen. Heidi Petracek reports.
What was tamoxifen originally used for?
It was within this Oral Contraception project that tamoxifen (Nolvadex), a triphenylethylene derivative, was synthesized and subsequently developed, initially as a contraceptive pill.
Is tamoxifen toxic to the liver?
Introduction. Tamoxifen is a nonsteroidal antiestrogen that is widely used in the treatment and prevention of breast cancer. Long term tamoxifen therapy has been associated with development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury.
What is the monthly cost of tamoxifen?
Table 2
| Medication | Monthly cost in gap | |
|---|---|---|
| Median of state mean costs | Median of state mean costs | |
| Aromasin/Exemestane | 42.57 (40.72-50.94) | 13.66 (13.07-13.79) |
| Femara/Letrozole | 41.92 (39.38-51.11) | 14.16 (12.96-14.34) |
| Tamoxifen | 6.19 (5.95-9.22) | 2.26 (2.20-2.70) |
How much is tamoxifen at Walmart?
Average 12 Month Prices for Tamoxifen Citrate
| Pharmacy | Tamoxifen Citrate Retail Price | Tamoxifen Citrate SingleCare Price |
|---|---|---|
| Walmart | $55.95 | $36.28 |
| Walgreens | $80.10 | $40.88 |
| Kroger Pharmacy | $39.90 | $22.05 |
| Albertsons Pharmacy | $87.26 | $18.72 |
What drug company makes tamoxifen?
Today, tamoxifen is one of the world’s best-selling hormonal breast cancer drugs. However, it was not always so. Compound ICI 46,474 (as it was first known) was synthesized in 1962 within a project to develop a contraceptive pill in the pharmaceutical laboratories of ICI (now part of AstraZeneca).