Which antibiotics have ototoxicity effect?
Of all ototoxic drugs, the aminoglycosides are the most vestibulotoxic, although they vary greatly in their differential effects on the vestibular and cochlear systems. Kanamycin, amikacin, neomycin, and dihydrostreptomycin are preferentially cochleotoxic.
Does amikacin affect hearing?
Patients using amikacin had a greater risk of developing the more severe forms of hearing loss than those using kanamycin (adjusted odds ratio (OR) = 4.0, 95 % CI: 1.5–10.8).
Do tetracyclines cause ototoxicity?
Medicine-induced ototoxicity is the functional impairment of the inner ear (cochlea and/or vestibular system) or eighth cranial nerve secondary to a pharmaceutical agent1….Key Messages.
| Medicine Class | Examples |
|---|---|
| Medicines recognised as causing hearing loss | |
| Antibiotics | Aminoglycosides, macrolides, tetracyclines, vancomycin |
Is amikacin ototoxic?
Amicacin, as well as other aminoglycosides, are ototoxic drugs used in clinical practice, namely as second-line treatment of pulmonary tuberculosis, as in the present case.
Which antibiotics can cause hearing loss?
Which antibiotics can cause hearing loss?
- Streptomycin.
- Neomycin.
- Vancomycin.
- Amikacin (Amikin)
- Gentamicin (Garamycin)
- Kanamycin (Kantrex)
- Paromomycin (Humatin)
- Tobramycin (Tobi)
Which antibiotics cause nephrotoxicity and ototoxicity?
The aminoglycoside antibiotic gentamicin can cause both ototoxicity and nephrotoxicity, the severity of which varies with circadian time of daily treatment. However, it is not yet resolved if such drug-induced adverse effects are independent or dependent phenomena.
Which aminoglycoside is most ototoxic?
Neomycin is considered the most highly toxic; followed by gentamicin, kanamycin, and tobramycin; while amikacin and netilmicin are considered the least toxic.
Which antibiotics cause deafness?
Is doxycycline an ototoxic?
Mechanisms of Drug-Induced Ototoxicity Drugs associated with tinnitus include salicylates, quinine, streptomycin, neomycin, indomethacin, doxycycline, furosemide, metals, and caffeine.
Is ciprofloxacin ototoxic?
Topical ciprofloxacin is a safe and uncomplicated ototoxic drug that is an effective antibiotic used in the treatment of refractory chronic otitis those dregs such as pseudomonas aerogenusa and staphylococci resistant to methicillin are responsible for it, which in the usual doses has not harmful effects on hearing …
What antibiotic is most likely to cause damage to the ear?
Some common aminoglycosides that are capable of damaging hearing are: Streptomycin. Neomycin. Vancomycin.
Which drugs is nephrotoxic as well as ototoxic?
It is well established that many drugs, such as the aminoglycoside antibiotics and the chemotherapeutic drug cisplatin, are capable of inducing both nephrotoxicity and ototoxicity.