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Why does Dilantin cause gingival hyperplasia?

Why does Dilantin cause gingival hyperplasia?

Phenytoin has been shown to induce gingival overgrowth by its interaction with a subpopulation of sensitive fibroblasts. Cyclosporine has been suggested to affect the metabolic function of fibroblast (eg, collagen synthesis, breakdown).

Which anticonvulsant drug has the side effect of gingival hyperplasia?

Phenytoin and valproic acid have historically been known to cause gingival overgrowth in epileptic patients.

Do ACE inhibitors cause gingival hyperplasia?

Among them 71.1% were taking calcium channel blocker, 21.5% were taking ACE Inhibitors, and 7.4% were taking beta-blockers. Conclusions: Patients taking antihypertensive agents are at increased risk for gingival enlargement and inflammation is an important cofactor for the expression of this effect.

Does metoprolol cause gingival hyperplasia?

The frequency of GO was significantly higher in nifedipine-treated cases than other drug groups. Frequency of GO was 75% for nifedipine, 31.4% for amlodipine and 25% for amlodipine + metoprolol. Higher gingival, plaque and calculus were observed in patients taking calcium channel blockers.

Which antihypertensive causes gingival hyperplasia?

Amlodipine, a calcium channel blocker, used as antihypertensive drug has been found associated with gingival hyperplasia.

Does nifedipine cause gingival hyperplasia?

The principal action of nifedipine is to inhibit the influx of extracellular calcium ions across the membranes of cardiac and vascular smooth muscle cells, without changing serum calcium concentration (1). One of the side effects of this drug is gingival hyperplasia which was first described in 1984 by Lederman (2).

Does HCTZ cause gingival hyperplasia?

Probably, the ability of hydrochlorothiazide to eliminate sodium and water has an anti-hypertrophic effect even at the peripheral cellular level. Gingival overgrowth seems to be a collateral effect that accompanies these medications.

Why does amlodipine cause gingival hyperplasia?

Many of the calcium channel blockers used as antihypertentive drugs have been implicated in causing gingival enlargement. Amlodipine is dihydropyridine derivative used as antihypertensive drug having longer action and comparatively lesser side effect than Nifedipine (calcium channel blocker).

Does verapamil cause gingival hyperplasia?

Twenty-four dentate patients who received verapamil for more than 1 year were identified. Of these, gingival hyperplasia occurred in 1 patient (4.1%) that was limited to the mandibular attached gingiva. Onset of gingival overgrowth was associated with drug dosage, bacterial accumulation, and gingival inflammation.

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