Why glacial acetic acid is used in preparation of acetanilide?

Glacial acetic acid is used because it is an excellent polar protic solvent capable of dissolving acetanilide. For the process, acetanilide is first dissolved in the solvent, glacial acetic acid, by warming.

How does aniline react with acetic anhydride?

Aniline reacts with acetic anhydride to form acetanilide.

What is role of glacial acetic acid in acetylation reaction?

Answer: Acetylation of phenols with glacial acetic acid in presence of phospho- rus pentoxide gives the O-acetyl derivatives in yields of 10 to 40 per cent.

What is the role of acetic acid in acetylation reaction?

Acetylation is an organic esterification reaction with acetic acid. It introduces an acetyl functional group into a chemical compound. Such compounds are termed acetate esters or acetates. Deacetylation is the opposite reaction, the removal of an acetyl group from a chemical compound.

What is the role of acetic anhydride in acetanilide from aniline reaction?

Aniline or phenylamine is a primary amine and basic in nature. Acetic anhydride, an anhydride of acetic acid, acts as a source of acyl group here . Aniline reacts with acetic anhydride to form Acetanilide by nucleophilic substitution reaction and the reaction is called acetylation.

Which reaction occurs in the preparation of acetanilide?

Acetanilide is prepared from aniline when it reacts with acetic anhydride/glacial acetic acid in the presence of zinc dust. A mixture of aniline, glacial acetic acid, acetic anhydride and zinc dust is refluxed under anhydrous condition and then poured the mixture into ice cold water to get acetic anhydride precipitate.

What type of reaction is the synthesis of acetanilide?

nucleophilic substitution reaction
Aniline reacts with acetic anhydride to form Acetanilide by nucleophilic substitution reaction and the reaction is called acetylation. In this reaction, aniline acts as the nuclepohile and acyl (CH3CO-) group from acetic anhydride acts as the electrophile.

What is the principle on the acetylation of acetanilide?

Principle: Acetanilide is synthesized from aniline by acetylating it with acetic anhydride in presence of glacial acetic acid. Aniline or phenylamine is a primary amine and basic in nature. Acetic anhydride, an anhydride of acetic acid, acts as a source of acyl group here .