How does oxidative stress affect the development of diabetes?
Oxidative stress plays a pivotal role in the development of diabetes complications, both microvascular and cardiovascular. The metabolic abnormalities of diabetes cause mitochondrial superoxide overproduction in endothelial cells of both large and small vessels, as well as in the myocardium.
Is diabetic cardiomyopathy reversible?
This condition largely reversed by appropriate blood glucose control and RAAS inhibition after 60 days. To conclude, uncontrolled DM and hyperglycaemic crisis such as DKA and HHS may result in cardiotoxicity, acute left ventricular systolic dysfunction and DC.
Does oxidative stress cause insulin resistance?
Oxidative stress is a fundamental problem of metabolic syndromes including type 2 diabetes. ROS cause insulin resistance in the peripheral tissues by affecting various points in insulin receptor signal transduction, ultimately resulting in decreased expression of GLUT4 transporter in the cellular membrane [57].
Can Type 2 diabetes cause oxidative stress?
The pathophysiology of type 2 diabetes mellitus reveals that oxidative stress is one of the factors that plays a role in the pathogenesis of insulin resistance, impaired insulin secretion, glucose utilization, impaired hepatic glucose metabolism coupled with activation of inflammation pro-inflammation cytokines.
What are the symptoms of oxidative stress?
Oxidative stress can lead to symptoms such as:
- Fatigue.
- Memory loss or brain fog.
- Muscle and/or joint pain.
- Wrinkles.
- Gray hair.
- Decreased eyesight.
- Headache.
- Sensitivity to noise.
What is the best treatment for diabetic cardiomyopathy?
Administration of beta-blockers, angiotensin converting enzyme inhibitors (ACEi)/angiotensin receptor blockers (ARB) are currently the standard treatment for chronic HF with or without diabetes.
How common is diabetic cardiomyopathy?
Conclusion. Diabetic cardiomyopathy is relatively common in the community with a prevalence of 1.1%. The morbidity and mortality of patients with diabetic cardiomyopathy is high.
Are antioxidants good for diabetics?
Dietary antioxidants have been hypothesized to have a protective effect against the development of diabetes by inhibiting peroxidation chain reactions (2). It seems plausible that a sufficient intake of antioxidants plays an important role in protection against type 2 diabetes.
How do you recover from oxidative stress?
Lifestyle and dietary measures that may help reduce oxidative stress in the body include:
- eating a balanced, healthful diet rich in fruits and vegetables.
- limiting intake of processed foods, particularly those high in sugars and fats.
- exercising regularly.
- quitting smoking.
- reducing stress.