What is Brugia malayi infection clinically?

B. malayi is one of the causative agents of lymphatic filariasis, a condition marked by infection and swelling of the lymphatic system. The disease is primarily caused by the presence of worms in the lymphatic vessels and the resulting inflammatory response of the host.

Who discovered Wuchereria bancrofti?

In 1876 and 1877, Joseph Bancroft in Brisbane, Australia found adult worms in lymphatic abscesses in patients with larvae in the blood. He sent them to Spencer Cobbold in London who named them Filaria Bancrofti. Patrick Manson in Xiamen, China (then called Amoy) made two important observations.

Is Brugia timori sheathed?

Microfilaria of Brugia timori are sheathed and measure on average 310 µm in stained blood smears and 340 µm in 2% formalin. Microfilaria of B. timori differ from B. malayi by a having a longer cephalic space, a sheath that does not stain with Giemsa, and a larger number of single-file nuclei towards the tail.

Who discovered elephantiasis?

In 1866, Timothy Lewis, building on the work of Jean Nicolas Demarquay and Otto Henry Wucherer, made the connection between microfilariae and elephantiasis, establishing the course of research that would ultimately explain the disease. In 1876, Joseph Bancroft discovered the adult form of the worm.

Who discovered brugia timori?

16.3. including Brugia malayi and Brugia timori) (WHO, 2017c). The disease was first described about 600 BCE (BC) by Persian and Hindu physicians (Otsuji, 2011). The adult worms are found in the lymphatic vessels depressing lymph flow and thereby causing edema (WHO, 2017c).

How is Brugia malayi transmitted?

The typical vector for Brugia malayi filariasis are mosquito species from the genera Mansonia and Aedes. During a blood meal, an infected mosquito introduces third-stage filarial larvae onto the skin of the human host, where they penetrate into the bite wound .

Is Brugia malayi nocturnal?

Nocturnal subperiodicity: microfilariae are present in the blood at all times, but appear at greatest density between noon and 8 PM [4]. Brugia malayi is transmitted by a mosquito vector. The principle mosquito vectors include Mansonia, Anopheles, and Aedes mosquitoes [5]….