Why clozapine is used in refractory schizophrenia?

Clozapine is also indicated in patients with schizophrenia who show severe, untreatable adverse neurological reactions to other antipsychotics, including second-generation antipsychotics. Treatment with clozapine decreases overall mortality in schizophrenia, in part by reducing suicidality.

What is the treatment for treatment-resistant schizophrenia?

Clozapine remains the first-line medication for treatment-refractory psychotic symptoms. In cases of partial response, the combination with SGAs such as sulpiride, amisulpride, aripiprazole, ziprasidone and risperidone is justified in order to supplement its antidopaminergic properties.

Which of the following drug is indicated in refractory schizophrenia?

Abstract. Objective: Clozapine remains the only medication indicated for refractory schizophrenia. As new antipsychotic drugs become available, their efficacy compared to clozapine, particularly in moderately ill patients, is of great clinical interest.

What is the most effective treatment for schizophrenia?

Antipsychotics. Antipsychotics are usually recommended as the initial treatment for the symptoms of an acute schizophrenic episode. They work by blocking the effect of the chemical dopamine on the brain.

Why is clozapine a last resort?

Clozapine has unique and powerful side effects and risks, which often make it a drug of last resort.

What to do when antipsychotics dont work?

If you are taking an antipsychotic which you feel is not working, or if the side effects are difficult to live with, then you should discuss this with your GP or psychiatrist. You should not stop taking antipsychotics suddenly.

Why might someone with schizophrenia resist treatment?

Fear of Stigma. It’s estimated that half of all people in the United States with mental illness don’t receive treatment. Part of the reason is that mental illness carries a stigma—and schizophrenia is no exception. Many people don’t truly understand the illness, and they may react with fear or discrimination.

What medication can replace clozapine?

Loxapine can be an excellent alternative to clozapine. It is comparable to clozapine in efficacy, cost-effectiveness, and a better side effect profile with more administration routes.